Module Details
| Module Code: |
BIOT6015 |
| Title: |
Bioprocess Eng Principles
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Long Title:
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Bioprocess Engineering Principles
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| NFQ Level: |
Fundamental |
| Valid From: |
Semester 1 - 2024/25 ( September 2024 ) |
| Field of Study: |
4218 - Biotechnology
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| Module Description: |
This module will provide an insight into the role of the Chemical & Bio-pharmaceutical Engineer in the manufacture of biotechnological products from cell line to final product. This module will introduce cellular vectors and their constituent parts and quantitative aspects of bio-process engineering such as bio-stoichiometry, material and energy balances on biological systems, modelling and sterilization of batch and continuous microbial bioreactors.
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| Learning Outcomes |
| On successful completion of this module the learner will be able to: |
| # |
Learning Outcome Description |
| LO1 |
Describe the structure and functionality of eucaryotic and procaryotic cell types and their organelles and macro-molecules. |
| LO2 |
Discuss production, safety, moral and ethical topics associated with the manufacture of high value/low volume and low value/high volume biotechnological products. |
| LO3 |
Calculate bio-stoichiometric coefficients and heats of reactions for biological system mass and energy balances. |
| LO4 |
Model microbial growth, substrate consumption, product formation and thermal deactivation in batch and continuous bioreactor systems. |
| LO5 |
Perform relevant practical based experiments, interpret results and complete laboratory reports. |
| Dependencies |
Module Recommendations
This is prior learning (or a practical skill) that is strongly recommended before enrolment in this module. You may enrol in this module if you have not acquired the recommended learning but you will have considerable difficulty in passing (i.e. achieving the learning outcomes of) the module. While the prior learning is expressed as named MTU module(s) it also allows for learning (in another module or modules) which is equivalent to the learning specified in the named module(s).
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Incompatible Modules
These are modules which have learning outcomes that are too similar to the learning outcomes of this module. You may not earn additional credit for the same learning and therefore you may not enrol in this module if you have successfully completed any modules in the incompatible list.
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| No incompatible modules listed |
Co-requisite Modules
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| No Co-requisite modules listed |
Requirements
This is prior learning (or a practical skill) that is mandatory before enrolment in this module is allowed. You may not enrol on this module if you have not acquired the learning specified in this section.
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| None |
| Indicative Content |
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Bio-molecules and Cells
Structure and function of carbohydrates, proteins and fats and nucleic acids. The structure of typical eucaryotic and prokaryotic cells and their organelles.
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The colours of biotechnology
Social, moral and ethical considerations. GM foods. Applications of human and animal genetic research. Regulatory requirements. Euro-barometers. Genetic engineering safety. Bio-hazards. Wastewater characterisation and treatment, anaerobic digestion and bio-remediation (green). Production of compounds from marine microbes and bio-fuels from algae (blue). Manufacture of bio-pharmaceutical products and production methods (red). First and second generation bio-fuel production, bio-refineries, antibiotic and beer production (white).
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Bioproduct production processes
Key differentiators of high value/low volume and low value/high volume processes. Case studies: Beer production & Interferon production.
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Bioreactor Design
Key features and functions of bioreactors. Bioreactor feeding regimes and productivity. Heat of reaction for bio-processes. Stoichiometry of cell growth and product formation. Material and energy balances on batch and continuous systems.
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Bioreactor modelling
Modelling and kinetics of micro-organism growth and thermal deactivation in batch and continuous systems.
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Laboratory Programme
Laboratory skills, water chemistry, bioprocess instrumentation, enzyme activity, microbial growth, substrate concentration measurement, cell concentration measurement, product concentration measurement, brewing (mashing/fermentation/bottling).
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Module Content & Assessment
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| Assessment Breakdown | % |
|---|
| Coursework | 100.00% |
Assessments
| No End of Module Formal Examination |
| Reassessment Requirement |
Coursework Only
This module is reassessed solely on the basis of re-submitted coursework. There is no repeat written examination.
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The University reserves the right to alter the nature and timings of assessment
Module Workload
| Workload: Full Time |
| Workload Type |
Contact Type |
Workload Description |
Frequency |
Average Weekly Learner Workload |
Hours |
| Lecture |
Contact |
Classroom Instruction |
Every Week |
2.00 |
2 |
| Lab |
Contact |
Practicals |
Every Week |
2.00 |
2 |
| Independent & Directed Learning (Non-contact) |
Non Contact |
Student Study |
Every Week |
3.00 |
3 |
| Total Hours |
7.00 |
| Total Weekly Learner Workload |
7.00 |
| Total Weekly Contact Hours |
4.00 |
| Workload: Part Time |
| Workload Type |
Contact Type |
Workload Description |
Frequency |
Average Weekly Learner Workload |
Hours |
| Lecture |
Contact |
Classroom Instruction |
Every Week |
2.00 |
2 |
| Lab |
Contact |
Practicals |
Every Week |
2.00 |
2 |
| Independent & Directed Learning (Non-contact) |
Non Contact |
Student Study |
Every Week |
3.00 |
3 |
| Total Hours |
7.00 |
| Total Weekly Learner Workload |
7.00 |
| Total Weekly Contact Hours |
4.00 |
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Module Resources
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| Recommended Book Resources |
|---|
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Reinhard Renneberg. (2023), Biotechnology for Beginners, Elsevier, p.474, [ISBN: 9780323855693].
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Matthew Farber and Roger Barth. (2019), Mastering Brewing Science, 1st. Wiley-Blackwell, p.592, [ISBN: 9781119456056].
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Gary Walsh. (2014), Proteins, John Wiley & Sons, p.447, [ISBN: 9780470669853].
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Pauline M. Doran. (2013), Bioprocess Engineering Principles, 2nd Ed.. Academic Press, p.929, [ISBN: 978-0122208515].
| | Supplementary Book Resources |
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Michael L. Shuler, Fikret Kargı. Bioprocess Engineering, 2nd Ed.. [ISBN: 978-0131228573].
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Colin Ratledge, Bjorn Kristiansen (Eds.). (2006), Basic Biotechnology, 3rd Ed.. Cambridge University Press, p.679, [ISBN: 978-0521549585].
| | This module does not have any article/paper resources |
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| Other Resources |
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Website, The Chemical Engineer,
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Laboratory Manual, MTU. Bioprocess Engineering Laboratory Manual.
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