Module Details

Module Code: BIOL8014
Title: Haematology Disorders
Long Title: Haematology Disorders
NFQ Level: Advanced
Valid From: Semester 1 - 2022/23 ( September 2022 )
Duration: 1 Semester
Credits: 5
Field of Study: 4211 - Biochemistry & Cell Biology
Module Delivered in: 1 programme(s)
Module Description: This module focuses on Haematology Disorders, primarily the Haematological Malignancies and disorders of Haemostasis.
 
Learning Outcomes
On successful completion of this module the learner will be able to:
# Learning Outcome Description
LO1 Discuss the role and interaction of the different components of haemostasis.
LO2 Integrate and assess clinical and laboratory findings in haematolgical disorders.
LO3 Differentiate between the different haematological malignancies and benign white blood cell disorders.
LO4 Assess the diagnosis, treatment regimens and management of haematological malignancies and haemostatic disorders using best practice guidelines.
Dependencies
Module Recommendations

This is prior learning (or a practical skill) that is strongly recommended before enrolment in this module. You may enrol in this module if you have not acquired the recommended learning but you will have considerable difficulty in passing (i.e. achieving the learning outcomes of) the module. While the prior learning is expressed as named MTU module(s) it also allows for learning (in another module or modules) which is equivalent to the learning specified in the named module(s).
Incompatible Modules
These are modules which have learning outcomes that are too similar to the learning outcomes of this module. You may not earn additional credit for the same learning and therefore you may not enrol in this module if you have successfully completed any modules in the incompatible list.
No incompatible modules listed
Co-requisite Modules
No Co-requisite modules listed
Requirements

This is prior learning (or a practical skill) that is mandatory before enrolment in this module is allowed. You may not enrol on this module if you have not acquired the learning specified in this section.
No requirements listed
 
Indicative Content
Normal Haemostasis
Components of normal haemostasis and their interaction.
Pre Analytical Variables
The effect of different pre analytical variables in haemostasis testing.
Bleeding Disorders
Vascular, platelet and coagulation disorders (inherited and acquired); clinical features their laboratory investigation.
Thrombotic Disorders
Arterial thrombosis, venous thrombosis, thrombophilia; clinical features and laboratory investigation and findings
Anticoagulants and other Therapies and Agents for Thrombosis
Management of thrombotic disorders; oral anticoagulation, heparins, novel anticoagulant agents, fibrinolytic agents and antiplatelet drugs. laboratory monitoring of treatments.
Laboratory Investigations of Haemostasis
Principles of laboratory analysis, automation, calibration, control, coagulation screens and first line tests, second line investigation-; correction tests, inhibitor tests, assays. Investigation of platelets and platelet function, investigation of Haemophilia and other coagulation deficiencies and von Willibrand disease. Investigation of vascular defects.
Laboratory Investigation of Thrombotic Tendencies
Investigation of thrombophilia - antithrombin assays, Protein C assay, Protein S assay, Activated Protein C resistance and Factor V Leiden, Prothrombin 20210, Lupus anticoagulant. Investigation of a suspected dysfibrinogeaemia. Investigation of fibrinolytic potential. Markers of coagulation activation, activated factor V11a, Global test of coagulation (thromboelastography).
Laboratory Control of Anticoagulant, thrombolytic and antiplatelet therapy
Oral anticoagulant-; standardisation of control, calibrations of thromboplastins, determination of INR, therapeutic range, choice of thromboplastins. Heparin treatment-; laboratory control, APTT, monitoring at the bedside, anti Xa assay, ptotamine neutralisation test, heparin induced thrombocytopenia (HIT), Thrombolytic Therapy and laboratory control, Antiplatelet Therapy and laboratory control.
Acute Leukaemias
Aetiology, classification, clinical features, laboratory investigation and management.
Chronic Myeloid Leukaemia
Aetiology, clinical features, laboratory investigation and management.
Myelodysplasia
Aetiology, classification,clinical features, laboratory investigation and management.
Chronic Lymphoid Leukaemia
Aetiology, classification, clinical features, laboratory investigation and management.
Hodgkins Lymphoma and Non Hodgkins Lymphoma
Aetiology, clinical features, histological classification, staging and laboratory investigation, management.
Multiple Myeloma
Paraproteinaemia, multiple myeloma, other plasma cell tumours, Waldenstrom macroglobinaemia; clinical features, diagnosis and management.
Myeloproliferative disorders
Polycythaemia, Essential Thrombocythaemia, Myelofibrosis; diagnosis and laboratory investigation, clinical features and management.
Benign White Blood Cell Disorders
Granulocytes, monocytes, lymphocytes and their benign disorders.
Laboratory Techniques in the Investigation of Haematological Malignancies
The principle and application of some of the tests that aid in the diagnosis and the classification of Haematological Malignancies will be discussed-; Blood film microscopy, Bone Marrow microscopy, cytochemistry, immunophenotyping, chromasomal and molecular analysis.
Case Studies
A number of haematology case studies maybe reviewed.
Module Content & Assessment
Assessment Breakdown%
Coursework100.00%

Assessments

Coursework
Assessment Type Other % of Total Mark 40
Timing Week 7 Learning Outcomes 1,2
Assessment Description
Assessment including questions and case studies
Assessment Type Critique % of Total Mark 60
Timing Week 13 Learning Outcomes 2,3,4
Assessment Description
Assessment with questions requiring critical analysis of students understanding of haematological disorders, their diagnosis, differential diagnosis and detection
No End of Module Formal Examination
Reassessment Requirement
Repeat examination
Reassessment of this module will consist of a repeat examination. It is possible that there will also be a requirement to be reassessed in a coursework element.

The University reserves the right to alter the nature and timings of assessment

 

Module Workload

Workload: Full Time
Workload Type Contact Type Workload Description Frequency Average Weekly Learner Workload Hours
Lecture Contact Haematology Every Week 2.00 2
Independent & Directed Learning (Non-contact) Non Contact Haematology Every Week 5.00 5
Total Hours 7.00
Total Weekly Learner Workload 7.00
Total Weekly Contact Hours 2.00
This module has no Part Time workload.
 
Module Resources
Recommended Book Resources
  • Victor Hoffbrand, David P. Steensma. (2019), Essential Haematology, Includes a companion website, 8th. Wiley Blackwell, [ISBN: 978-1-119-495].
Supplementary Book Resources
  • Andrew Blann, Gavin Knight, Gary Moore. (2016), Haematology, 2nd. Oxford, p.661, [ISBN: 9780199668861].
  • Barbara J. Bain, Imelda Bates, Mike A. Laffan. (2016), Dacie and Lewis Practical Haematology, 12th. Elsevier, [ISBN: 9780702069307].
This module does not have any article/paper resources
This module does not have any other resources
 
Module Delivered in
Programme Code Programme Semester Delivery
CR_SBISC_8 Bachelor of Science (Honours) in Biomedical Science 7 Mandatory