Module Details

Module Code: BIOL8013
Title: Transfusion & Transplantation
Long Title: Transfusion & Transplantation
NFQ Level: Advanced
Valid From: Semester 1 - 2021/22 ( September 2021 )
Duration: 1 Semester
Credits: 5
Field of Study: 4211 - Biochemistry & Cell Biology
Module Delivered in: 1 programme(s)
Module Description: This module will focus on Transfusion Regulation, Haemovigilance, Blood Groups systems and disorders associated with immune red cell destruction. Also current aspects of Transfusion Microbiology, Haemopoietic and Solid Transplantation will be reviewed
 
Learning Outcomes
On successful completion of this module the learner will be able to:
# Learning Outcome Description
LO1 Discuss the regulations that apply to blood transfusion practice
LO2 Debate the microbiological risks associated with blood transfusion
LO3 Discuss the importance of the HLA system and the immunogenics laboratory in transfusion and transplantation.
LO4 Review the clinically important blood group systems and the disorders associated with immune cell destruction.
LO5 Identify recent developments in clinical and laboratory transfusion and transplantation practice.
Dependencies
Module Recommendations

This is prior learning (or a practical skill) that is strongly recommended before enrolment in this module. You may enrol in this module if you have not acquired the recommended learning but you will have considerable difficulty in passing (i.e. achieving the learning outcomes of) the module. While the prior learning is expressed as named MTU module(s) it also allows for learning (in another module or modules) which is equivalent to the learning specified in the named module(s).
Incompatible Modules
These are modules which have learning outcomes that are too similar to the learning outcomes of this module. You may not earn additional credit for the same learning and therefore you may not enrol in this module if you have successfully completed any modules in the incompatible list.
No incompatible modules listed
Co-requisite Modules
No Co-requisite modules listed
Requirements

This is prior learning (or a practical skill) that is mandatory before enrolment in this module is allowed. You may not enrol on this module if you have not acquired the learning specified in this section.
No requirements listed
 
Indicative Content
Transfusion Practice Regulated
EU Directive, Quality Management Principles and Systems, Irish Legislation and Transfusion Practice, Irish Medicine Board, Irish National Accreditation Authority, ISO15189, Hospital Blood Bank Requirements, traceability, Reporting serious adverse reactions and serious adverse events,
Haemovigilance
History of Haemovigilance, competent authority, responsibility, funding, role and structure of national haemovigilance office, national blood users group, reporting systems, UK SHOT system, serious adverse reactions and serious adverse events. developments.
Transfusion Associated Bacterial Sepsis (TABS)
Transfusion associated bacteria sepsis: Incidence, organisms implicated and associated blood components, intervention and prevention, investigation.
Transfusion Microbiology
Emerging Pathogens, West Nile Virus, Hepatitis E, Zika Virus. Transfusion transmitted Infections associated Hepatitis B, Hepatitis C, Human Immuno Deficiency Virus, Cytomegalo Virus, Human T cell Leukaemia Virus, variant CJD. Risk reduction measures, including donor selection measures and laboratory testing and pathogen reduction techniques.
Developement in Transfusion Practice and Component Therapy
Red cells, platelets, plasma, manufactured blood products and derivatives, haemopoietic growth factors. Blood component modification and blood substitutes.
Blood Group Systems
The Kell, Duffy and Kidd Blood Group Systems. MNS, Lewis, P, Lutheran and other systems
Human Leucocyte Antigen System
HLA system, MHC, HLA techniques, Disease association, Clinical significance of HLA system.
Transplantation
Solid organ ( renal, pancreas, liver, eye) transplants, bone marrow and stem cells transplants. Donor registries. Factors that determine successful transplant. Transplant rejection.
Platelet and Neutrophils Antigens.
Human platelet antigens, platelet antibodies and clinical significance. Neutrophil antigens, platelet antibodies and clinical significance
Haemolytic Disease of the Foetus-Newborn
Clinical and Laboratory Aspects of HDN-HDF. The role of the blood transfusion laboratory in the prediction, prevention and management of the haemolytic disease.
Auto Immune Haemolytic Anaemia
Auto Immune Haemolytic Anaemia - Warm autoimmune haemolytic anaemia, Cold agglutinin syndrome and Paroxysmal Haemoglobinurea, Drug Induced Haemolytic Anaemia. Strategies for solving serological problems associated with the different types of autoimmune haemolytic anaemia.
Tissue Banking
Consent, donor selection - criteria and enquiry, donor testing, processing facilities,tissue procurement, tissue processing, tissue products and their issues, classifications, standards and quality issues.
Cord Banking
Related and unrelated cord banking, recruitment, interview, testing. processing, storage.
Module Content & Assessment
Assessment Breakdown%
Coursework20.00%
End of Module Formal Examination80.00%

Assessments

Coursework
Assessment Type Multiple Choice Questions % of Total Mark 20
Timing Week 7 Learning Outcomes 2,3,4
Assessment Description
Transfusion Science
End of Module Formal Examination
Assessment Type Formal Exam % of Total Mark 80
Timing End-of-Semester Learning Outcomes 1,2,3,4,5
Assessment Description
End-of-Semester Final Examination
Reassessment Requirement
Repeat examination
Reassessment of this module will consist of a repeat examination. It is possible that there will also be a requirement to be reassessed in a coursework element.

The University reserves the right to alter the nature and timings of assessment

 

Module Workload

Workload: Full Time
Workload Type Contact Type Workload Description Frequency Average Weekly Learner Workload Hours
Lecture Contact Transfusion Science Every Week 2.00 2
Independent & Directed Learning (Non-contact) Non Contact No Description Every Week 5.00 5
Total Hours 7.00
Total Weekly Learner Workload 7.00
Total Weekly Contact Hours 2.00
This module has no Part Time workload.
 
Module Resources
Recommended Book Resources
  • Neil Advent. (2017), Transfusion and Transplantation Science, 2. Oxford, [ISBN: 978019873531].
Supplementary Book Resources
  • Harvey G. Klein, David J. Anstee. (2014), Mollison's Blood Transfusion in Clinical Medicine, 12. Wiley-Blackwell, p.994, [ISBN: 9781405199407].
  • Michael F. Murphy (Editor), Derwood H. Pamphilon (Editor), Nancy M. Heddle (Editor). (2013), Practical Transfusion Medicine, 4. Wiley-Blackwell, p.578, [ISBN: 9780470670514].
This module does not have any article/paper resources
This module does not have any other resources
 
Module Delivered in
Programme Code Programme Semester Delivery
CR_SBISC_8 Bachelor of Science (Honours) in Biomedical Science 8 Mandatory